Harnessing Nasal Immunity with IgA to Prevent Respiratory Infections

The nasal cavity is a primary checkpoint for the invasion of respiratory pathogens. Numerous pathogens, including SARS-CoV-2, S. pneumoniae, aureus, etc., can adhere/colonize lining to trigger an infection. Secretory IgA (sIgA) serves as first line immune defense against foreign sIgA facilitates clearance pathogenic microbes by intercepting their access epithelial receptors and mucus entrapment through exclusion. Elevated levels neutralizing at mucosal surfaces are associated with high level protection following intranasal immunizations. This review summarizes recent advances in vaccination technology challenges maintaining nominal surface. Overall, emphasizes significance IgA-mediated immunity, which holds tremendous potential mount